ABSTRACT
Objective:To compare the efficacy and safety of endoscopic digestive resection and laparoscopic surgery in the treatment of gastric stromal tumor with diameter<3.5 cm.Methods:Stratified sampling was used to select 100 patients with diameter<3.5cm gastric stromal tumor from January 2018 to January 2020 in Yuncheng Central Hospital, and they were divided into two groups by touching the ball method.The control group (50 cases) was treated with laparoscopic surgery, and the observation group (50 cases) was treated with digestive endoscopic resection.The therapeutic effects of the two groups were compared.Results:The operative time of the observation group was (63.51±13.52)min, which was shorter than that of the control group [(71.24±15.04)min] ( t=2.703, P=0.004). The intraoperative blood loss in the observation group was (38.15±2.55)mL, which was less than that in the control group [(40.12±3.56)mL] ( t=3.181, P=0.001). The postoperative fasting time of the observation group was (20.02±3.85)h, which was shorter than that of the control group [(22.12±2.96)h] ( t=3.058, P=0.001). The postoperative recover defecation time of the observation group was (18.61±1.89)h, which was shorter than that of the control group [(20.05±3.13)h] ( t=2.785, P=0.003). The length of hospital stay in the observation group was (6.25±1.96)d, which was shorter than that in the control group [(7.06±1.16)d] ( t=2.515, P=0.007). The incidence of complications was 4.00% in the observation group, and 8.00% in the control group, the difference between the two groups was statistically significant(χ 2=0.177, P=0.673). There was no statistically significant difference in tumor risk classification between the two groups ( Z=0.386, P=0.534). Conclusion:Endoscopic digestive resection in the treatment of gastric stromal tumor with diameter<3.5cm has advantages of short operation time, less bleeding and fast postoperative recovery, etc., and has certain efficacy and safety.
ABSTRACT
Objective To explore mechnism and effect of fentanyl on proliferation of gastric cancer SGC-7901 cell.Methods Gastric cancer SGC-7901 cell was cultured with fentanyl of 0 (negative control), 0.5, 5 and 50 nmol/L, MTT method was used to detect the effect of fentanyl on SGC-7901 viability.The effect of fentanyl on SGC-7901 cell cycle was measured by flow cytometry.The level of cell related protein,cell cycle protein cyclin D1, Bcl-2.Results Compared with control group, fentanyl (0.5, 5, 50 nmol/L) could inhibit SGC-7901 cell viability, and the inhibitory rate was highest at 48 h.0.5, 5, 50 nmol/L fentanyl made cell cycle arrested in G1 phase.Compared with control group, fentanyl can significantly inhibit cyclinD1 and Bcl-2 expression with drug concentration increasing(P<0.05).Conclusion These results suggeste fentanyl inhibit proliferation of gastric cancer SGC-7901 cell.